|
KMID : 0366219940290030287
|
|
Korean Journal of Hematology
1994 Volume.29 No. 3 p.287 ~ p.297
|
|
|
Effect of Treatment with Vincristine, Prednisolone, Daunorubicin, and L-aspara- ginase in Adult Acute Lyrnphocytic Leukemia
|
|
You Yong-Kyu
Lee Ho-Soo
Kim Joo-Ho
Park Jun-Young
Won Jong-Ho
Hong Dae-Sik
Park Hee-Sook
|
|
|
Abstract
|
|
|
Background : Although improvement in the management of adult acute Iympho-cytic leukemia(ALL) has not been as rapid as in the childhood form of this disease, progress has been achieved in remission induction rate and increased in survival.
Mlethods : Twenty previously untreated patients with ALL were treated with in-duction chemotherapy consisting of vincristine, prednisolone, daunorubicin, and L-asparaginane. After successful remission induction, Postremission therapy was Per- formed with CNS prophylaxis(cranial irradiation and intrathecal methotrexate) and maintenance chemotherapy (methotrexate and 6-mercaptopurine).
Results: 1) Seventeen out of twenty(85%) cases achieved complete remission. The median duration of remission and overall survival were 14.5 months(4-50 months) and 13mon1hs(1-15 months) respectively. 2) Three-year remission rate was 25% in CR patients, and 3-year survival rate was 21.1% in overall patients. 3) Two patients were refractory to induction chemotherapy, and one died from complication during induction therapy. Fifteen (88.2%) out of seventeen patients who had
achieved remission relapsed, and the sites of relapse were the bone marrow (80%), CNS(13.3%), and both(6.7%).
4) The median nadir of WBC and platelet were 600/㎣(200-1,400/㎣) and 18,000 /㎣ (1,000-87,000/㎣) during induction chemotherapy, and the median duration of the marrow recovery was 20 days(14-60 days). 5) Non-hematologic toxicities were nausea(100%), vomiting(100%), alopecia(100%), stomatitis(60%), diarrhea(45%), hepatotoxicity(40%), neurotoxicity(20%), neph-rotoxicity(5%), and increased amylase level(5%).
Conclusion : These data suggest that combination chemotherapy consisting of vincristine, prednisolone, daunorubicln, and L-asparaginase in adult ALL was useful to remission induction. In the future, intensive postremission therapy should be con-sidered to increase survival duration.
|
|
|
KEYWORD
|
|
|
Acute Iymphocytic leukemla, Combination chemotherapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|